WebMay 24, 2024 · Genotype and allelic frequency. The genotype and allele frequencies of the FOXO3 gene variants in the octogenarians and the GIT cancer patients are shown in … WebJul 19, 2024 · FOXO3 is a transcription factor with multiple biologic functions, including antioxidant response, longevity, and cell cycle control 14, 15, 16, 17, 18, 19; knockdown of FOXO3 arrests erythroid maturation, and activation of FOXO3 promotes erythroid maturation. 20, 21, 22, 23, 24 In numerous nonerythroid cell types, FOXO3 is also tightly …
FOXO3A genotype is strongly associated with human longevity
WebThe FoxO3 gene (FOXO3), and its homologs in model organisms, appears especially important, forming a key gene in the insulin/insulin-like growth factor-signaling pathway, … WebJan 24, 2024 · Our results show that FoxOs are suppressed in degenerated meniscus and that FoxO1 regulates meniscus growth and maturation, while both FoxO1 and 3 have … infinite technologies syracuse ny
FOXO3 protein expression summary - The Human Protein Atlas
WebSep 16, 2008 · This gene has widespread effects on aging phenotypes, particularly cardiovascular disease and dementia, and as such influences the ability to achieve a long and healthy life. To find other such genes, it may be helpful to use model organisms to identify a priori potential candidates before conducting human studies. The use of FOXO3a knockout mice has revealed a diverse range of functions in both health and disease, namely infertility, lymphoproliferation, adenoma, organ inflammation, metabolism etc.; yet despite the purported importance of FOXO transcription factors in aging, FOXO3A knockout mice do not … See more Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. See more FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription … See more Gopinath et al. (2014) demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling pathway (an essential regulator of See more Genetic variation in FOXO3 has been shown to be associated with healthspan and longevity in humans. It is found in most centenarians across a variety of ethnic groups around the world. The homologous genes daf-16 in the nematode C. elegans and dFOXO in the See more Yu & Fellows et al. (2024) demonstrated that FOXO3a activation in vascular smooth muscle cells induces prominent apoptosis and extracellular matrix breakdown in vitro and exacerbates See more Deregulation of FOXO3a is involved in tumorigenesis, for example translocation of this gene with the MLL gene is associated with secondary acute leukemia. Downregulation of FOXO3a activity is often seen in cancer (e.g. by increase in Akt activity … See more In a meta-analysis of 78,308 individuals of European descent, a particular single nucleotide polymorphism (SNP) (rs2490272) in an intronic region of FOXO3 and … See more infinite teacher texts