Flow acceleration osteocyte
WebDec 7, 2024 · The fluid flow hypothesis claims that a load-induced fluid flow through the lacunocanalicular network can be sensed by osteocytes, which reside within the network structure. We show that considering the network architecture results in a better … WebJan 10, 2012 · It should be noted that osteocytes subjected to fluid flow conditions with lower parameter values (e.g., 0.5 Pa or 1 Pa peak shear stress amplitudes, 0.5 Hz …
Flow acceleration osteocyte
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WebApr 9, 2024 · Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach Biomech Model Mechanobiol. 2014 Jan;13(1) :85-97. doi ... WebPrimary Osteocyte Cultures. Osteocytes are most often described as terminally differentiated osteoblasts that reside in small pockets termed lacunae, located deep within mineralized bone. Osteocytes are sensitive to mechanical strain, and in response to such stresses, communicate with surface osteoblasts and osteoclasts via a complex network …
WebNov 1, 2015 · The valid region in flow chamber should meet the conditions of L»H, W»H and L/H>10, so that the fluid could be the two dimension developed laminar flow. The residual acceleration was 1.7×10 −3 g to reach the simulated microgravity environment when the device rotated with 15 rpm rotation speed in our experiment. WebJan 14, 2015 · Flow stimulation further enhanced gene expression. In conclusion, we have demonstrated that 3D culture can influence osteocyte biology, promoting the expression of fgf23. We have also shown that both substrate stiffness and fluid flow can significantly influence osteocyte gene expression, demonstrating that fgf23 is a mechanically …
WebThe definition of an osteocyte is descriptive of its location (cells surrounded by mineralized matrix), not its function; as soon as osteoblasts become entrapped in the matrix they produce, they are called osteocytes. WebThe purpose of the current study is to demonstrate effects of osteocyte orientation on the deflection of fluid flow in bone by modeling osteocytes rotated by 0°, 30°, 45°, 60°, and 90 ...
WebApr 9, 2013 · Using representative models of the osteocyte and its environment with fluid–structure interaction (FSI) techniques, we examine both shear stresses on the cell …
WebApr 5, 2024 · Recently, it has become widely accepted that in vivo interstitial fluid flow, a type of dynamic oscillating fluid flow, can activate the production of signaling … flink tumbling windowWebJan 31, 2024 · Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling. However, the mechanisms underlying this process remain unclear. Autophagy, which is an evolutionarily preserved process, that occurs at a basal level when stimulated by multiple environmental stresses. flink transactionsourceWebJun 8, 2024 · Hindlimb unloading (HLU), which focuses on disuse conditions and mimics bone loss induced by trips to space and decreased activity, is also popular in studies. In … flink two stream joingreater iberia chamber of commerce leadershipWebMar 6, 2024 · Vibration stimuli have been proposed to provide mechanical loading adequate to increase fluid flow in bone and facilitate mechanotransduction [ 26, 27 ]. However, … flink tumblingprocessingtimewindowWebJan 11, 2024 · The fluid flow simulation predicts the generation of highly inhomogeneous flow patterns in the pericellular space, owing to the microscopic surface roughness of … flink tuple2 typeinformationWebMay 24, 2024 · MLO-Y4 cells were seeded in the osteocyte (OCY) channel of a device on collagen I (Fig. 2B), or on glass slides coated with collagen I for parallel plate flow chamber (PPFC) controls. The cells were grown to 80% confluence and stained with Fura-2 AM (Ex: 340 nm/380 nm, Em: 510 nm; Thermo Fisher, USA). flink typehint